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I used to use the Plastibond from Lion but I don't think it available any more so I changed to Evo-Stick Multi Purpose Impact, Instant Contact Adhesive which seems to work fine.
It is available from the DIY sheds for a few pounds.
I'm new to all this, so defer to the great experience in the above comments.
However, from my own experience, I use Polcore without glue to make large landscape prints and they have been great. The typical sizes are 40" x 20" and they look as good as any of the wood frames. The joints are tight and the product is also cheaper. A win, win for me.
I must admit to initially being sceptical, but a very experienced framer friend persuaded me to try it and I haven't looked back since.